Search results for "model [interaction]"
showing 10 items of 1495 documents
Intrinsic Hardy–Orlicz spaces of conformal mappings
2014
We define a new type of Hardy-Orlicz spaces of conformal mappings on the unit disk where in place of the value |f(x)| we consider the intrinsic path distance between f(x) and f(0) in the image domain. We show that if the Orlicz function is doubling then these two spaces are actually the same, and we give an example when the intrinsic Hardy-Orlicz space is strictly smaller.
Correction: Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan.
2018
[This corrects the article DOI: 10.1371/journal.pone.0163841.].
Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-dr…
2017
Background Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of the molecular mechanisms underlying drug action and resistance development. Hyperactivated fibroblast growth factor receptors (FGFRs) constitute a promising therapy target in several types of malignancies including lung cancer. The clinically approved small-molecule FGFR inhibitor nintedanib exerts strong cytotoxicity in FGFR-driven lung cancer cells. However, subcellular pharmacokinetics of this compound and its impact on therapeutic efficacy remain obscure. Methods 3-dimens…
Hemivariational Inequalities and Hysteresis
2001
Hemivariational inequalities introduced by P.D. Panagiotopoulos are generalizations of variational inequalities. This type of inequality problems arises, e.g. in variational formulation of mechanical problems whenever nonmonotone and multivalued relations or nonconvex energy functions are involved. Typical examples of such kind of phenomena are nonmonotone friction laws and adhesive contact laws. Mathematically these nonmonotone relations are described by means of generalized gradients (in sense of F.H. Clarke) of nonconvex potential functions. For applications and for their mathematical treatment we refer to [9],[10],[13]–[18].
Global sensitivity analysis for urban water quality modelling: comparison of different methods
2012
Sensitivity analysis represents an important step in improving the understanding and use of environmental models. Indeed, by means of global sensitivity analysis (GSA), modellers may identify both important (factor prioritization) and non-influential (factor fixing) model input factors. However, despite the potentialities of GSA methods, only few applications have been published in the field of urban drainage modelling. In order to fill this gap this paper presents a comparison among three GSA methods (SRC, Extended-FAST and Morris screening) on an urban drainage storm-water model. In particular, an exhaustive discussion on their peculiarities, applicability, and reliability is presented. S…
Assessing the Effect of the Economy for the Common Good System on Business Performance
2023
Extant literature has pointed to organizational hybridity to lever sustainable business transformation. Moreover, some authors hold that there is a possible trade-off between sustainability and performance. However, there is still little empirical evidence on the impact that such sustainability-driven hybridization systems have on performance. Thus, the present study’s main goal is to fill this gap by providing empirical evidence on the impact of the implementation of the Economy for the Common Good, as a sustainability-driven organizational system, on business performance. To do so, the authors relied on a sample of 206 businesses from five European countries. Then, the authors follo…
Analysis and design of sequencing rules for car sequencing
2009
Abstract This paper presents novel approaches for generating sequencing rules for the car sequencing (CS) problem in cases of two and multiple processing times per station. The CS problem decides on the succession of different car models launched down a mixed-model assembly line. It aims to avoid work overloads at the stations of the line by applying so-called sequencing rules, which restrict the maximum occurrence of labor-intensive options in a subsequence of a certain length. Thus to successfully avoid work overloads, suitable sequencing rules are essential. The paper shows that the only existing rule generation approach leads to sequencing rules which misclassify feasible sequences. We …
Designing a Multi‐Sided Platform business model assessment framework: a Dynamic Performance Management perspective
2019
The purpose of this research is to offer an assessment framework to validate multisided platform business models. For this aim, we propose a systemic perspective based on the dynamic performance management approach. This approach is particularly effective to make explicit the net of relationships between internal and external strategic resources, the value creation and capture drivers, and the way such drivers influence platform performances. The developed multisided platform business model assessment framework has been tested by using a success and a failure case, respectively, Airbnb and Take Eat Easy. Research originality results from the combination of multisided platform value creation…
Switching Synchronization and Metastable States in 1D Memristive Networks
2019
One-dimensional (1D) memristive networks are the simplest type of memristive networks one can imagine. Yet, despite their morphological simplicity, such networks represent an important class of memory networks characterized by the strongest interaction among the network components. This chapter reviews several important dynamical features of 1D memristive networks composed of realistic threshold-type memristive systems. First of all, the accelerated and decelerated switching regimes of memristive systems are introduced and exemplified. Secondly, the phenomenon of switching synchronization is presented. Finally, it is shown that metastable transmission lines composed of metastable memristive…
Heterometallic 3d−4f Polyoxometalate Derived from the Weakley-Type Dimeric Structure
2009
Polyanion [{Ce(H(2)O)(2)}(2)Mn(2)(B-alpha-GeW(9)O(34))(2)](8-) (1) constitutes the first example of a heterometallic 3d-4f cluster related to the Weakley-type dimeric structure, and it contains an unprecedented Ce(III)(2)Mn(III)(2)O(20) rhomblike moiety displaying dominant Ce(III)-Mn(III) ferromagnetic interactions.